| Dean Clark | 1 | New York Jets (2025) |
| Thayer Munford | 2 | Las Vegas Raiders (2022-24), New England Patriots (2025), Cleveland Browns (2025) |
| Gareon Conley | 5 | Oakland Raiders (2017-19), Houston Texans (2019-20), D.C. Defenders (UFL) (2024) |
| Devin Smith | 6 | New York Jets (2015-17), Dallas Cowboys (2019-20) |
| Steve Schott | 1 | Cleveland Gladiators (AFL) (2015) |
| Shawn Crable | 5 | New England Patriots (2008-10), New York Jets (2010), Hamilton Lions (CFL) (2011), Hamilton Tiger Cats (CFL) (2012) |
| Andy Alleman | 4 | New Orleans Saints (2007), Miami Dolphins (2008), Kansas Citiy Chiefs (2009), Indianapolis Colts (2010) |
| Willie Spencer Jr. | 1 | Chicago Bears (2002) |
| Ben Mast | 1 | Detroit Fury Arena Football (2002) |
| Erik White | 3 | Toronto Argonauts (CFL) (1994-95), British Columbia Lions (CFL) (1995), Amsterdam Admirals (NFL-Europe) (1996) |
| Chris Spielman | 11 | Detroit Lions (1988-95), Buffalo Bills (1996-97), Cleveland Browns (1999) |
| Kevin McClelland | 2 | Tampa Bay Bandits (USFL) (1984-85) |
| Mark Streeter | 8 | Detroit Lions (1980), Winnepeg Blue Bombers (CFL) (1982), Toronto Argonauts (CFL) (1982), Hamilton Tiger Cats (CFL) (1983-87) |
| Tommy Hannon | 8 | Minnesota Vikings (1977-84) |
| Willie Spencer, Sr. | 6 | Ottawa Rough Riders (CFL) (1973), Memphis Southmen (WFL) (1974-75), Minnesota Vikings (1976), New York Giants (1977-78) |
| Denny Franklin | 2 | Detroit Lions (1975-76) |
| Steve Luke | 6 | Green Bay Packers (1975-80), Atlanta Falcons (1980) |
| Will Foster | 3 | Philadelphia Eagles (1972), New England Patriots (1973-74) |
| Jerry Allen | 4 | Baltimore Colts (1966), Washington Redskins (1967-69) |
| Charlie Brown | 3 | Chicago Bears (1966-68), Buffalo Bills (AFL) (1968) |
| Ken Ivan | 1 | Toronto Argonauts (CFL) (1966) |
| Bob Vogel | 10 | Baltimore Colts (1963-72) |
| Jim Houston | 13 | Cleveland Browns (1960-72) |
| Jim Letcavits | 6 | Edmonton Eskimos (CFL) (1958-62), Montreal Allouettes (CFL) (1963) |
| Tom Stephens | 5 | Boston Patriots (AFL) (1960-64) |
| Homer Floyd | 1 | Edmonton Eskimos (CFL) (1959) |
| Walt Houston | 1 | Washington Redskins (1955) |
| Henry Ace Grooms | 1 | Los Angeles Rams (1951) |
| Charlie Anderson | 3 | Montreal Alouettes (CFL) (1949-50, 52) |
| Tommy James | 9 | Cleveland Browns (1948-55), Baltimore Colts (1956) |
| Horace Gillom | 10 | Cleveland Browns (1947-56) |
| Fred Cardinal | 1 | New York Yankees (1947) |
| Lindell Houston | 8 | Cleveland Browns (1946-53) |
| Harry Stuhldreher | 1 | Brooklyn Lions (1926) |
| Don Nelson | 1 | Canton Bulldogs (1926), Hammond Pros (1926) |
| Ben Roderick | 5 | Canton Bulldogs (1920, 23, 26), Cleveland Tigers (1921), Buffalo All Americans (1923), Buffalo Bisons (1927) |
| Dave Reese | 9 | Cincinnati Colts (Pre-NFL) (1915-17), Youngstown Patriots (Pre-NFL) (1917), Dayton Triangles (Pre-NFL) (1918-19), Dayton Triangles (APFA / NFL) (1920-23) |
| John Beck | 1 | Massillon Tigers (Pre-NFL) (1917) |
| Earl Blackburn | 2 | Cincinnati Colts (Pre-NFL) (1916), Massillon Tigers (Pre-NFL) (1917) |
| Fred Heyman | 1 | Massillon Tigers (Pre-NFL) (1916) |
| Stanfield Wells | 3 | Akron Indians (Pre-NFL) (1915), Shelby Blues (Pre-NFL) (1915), Cleveland Indians (Pre-NFL) (1916), Detroit (Pre-NFL) (1917), Akron Indians (1919) |
| Frank Bast | 3 | Massillon Tigers (Pre-NFL) (1905-06), All-Massillons (Pre-NFL) (1907) |
| Charles "Cy" Rigler | 1 | Massillon Tigers (Pre-NFL) (1903) |